MEG-1 (637-926)/PTPN4 N-Terminal GST Tag - Active Enzyme


Catalog number


Full name

MEG-1 (637-926)/PTPN4 N-Terminal GST Tag - Active Enzyme


20 μg


426.00 €

Go to shop   



Proteins & Peptides

Long description

MEG-1, also know as Serine/threonine phosphatase 4 regulatory subunit 1, PPP4R1 or PP4R1 is crucial to cellular function. The catalytic subunit of MEG-1 or protein phosphatase 4 (PP4C) is 65% identical to PP2AC at the amino acid level and has been placed in the type 2A family of phosphatases. MEG-1 has been highly conserved between species sharing 91% amino acid identity between human and Drosophila. MEG-1 is predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. MEG-1 is an essential enzyme in the development of Drosophila embryos.

Antibody come from

Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Ser133 of CREB

Other description

Provided in HEPES (pH 7.5) solution containing 150 mM NaCl, 100 µg per ml BSA and 50% glycerol .


not specified

Antigen-antibody binding interaction

MEG-1 (637-926)/PTPN4 N-Terminal GST Tag - Active Enzyme

Antibody is raised in


Antibody's reacts with


Antibody's reacts with these species

This antibody doesn't cross react with other species

Antibody's specificity

No Data Available


Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.

Antibody's suited for

Antibody can be used for Western blotting and dot blotting (1:1000 dilution). Optimal concentration should be evaluated by serial dilutions.



Relevant references

1. Abel, T. and Kandel, E. 'Positive and negative regulatory mechanisms that mediate long-term memory storage,' Brain Res. Rev. 26, 360-378 (1998)._x000B__x000B_2. Hunter, T. and Karin, 'The regulation of transcription by phosphorylation,' Cell 70, 375-387 (1992)._x000B__x000B_3, Johannessen, M, Delghandi, M.P. and Moens, U. 'What turns CREB on?' Cellular Signaling 16, 1211-1227 (2004)._x000B__x000B_4. Montminy, M. 'Transcriptional regulation by cyclic AMP,' Annu. Rev. Biochem. 66, 807-822 (1997)._x000B__x000B_5. Shaywitz, A.J. and Greenberg, M.E. 'CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals,' Annu. Rev. Biochem. 68, 821-861 (1999)._x000B__x000B_6. Silva, A.J., Kogan, J.H., Frankland, P.W. and Kida, S. 'CREB and memory,' Annu. Rev. Neurosci. 21, 127-148 (1998)._x000B__x000B_7. Soderling, T.R. and Derkach, V.A. 'Postsynaptic protein phosphorylation and LTP,' Trends Neurosci. 23, 75-80 (2000)._x000B__x000B_8. Karin M, Hunter T (1995) Transcriptional control by protein phosphorylation: Signal transmission from the cell surface_x000B_to the nucleus. Curr Biol 5:747-757. _x000B__x000B_9. Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia ZG, Greenberg ME_x000B_(2002) CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events._x000B_Neuron 34:221-233.

Protein number

see ncbi


This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.


Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.