HDAC6 - Active Enzyme
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Proteins & Peptides
Human HDAC6 (GenBank Accession No. BC069243), full length with N-terminal GST tag, MW= 159 kDa, expressed in baculovirus expression system. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
Antibody come from
Rabbit polyclonal AIM antibody was raised against a 13 amino acid peptide from near the amino terminus of human AIM.
Provided as solution in phosphate buffered saline with 0.02% sodium azide.
Antigen-antibody binding interaction
HDAC6 - Active Enzyme
Antibody is raised in
Antibody's reacts with
Antibody's reacts with these species
This antibody doesn't cross react with other species
No Data Available
Useful for the study of enzyme kinetics, screening inhibitors and selectivity profiling.
Antibody's suited for
AIM antibody can be used for the detection of AIM by Western blot at 0.5 Ð 1ug/ml. Optimal concentration should be evaluated by serial dilutions.
1) Miyazaki T, Hirokami Y, Matsuhashi N, et al. Increased susceptibility of thymocytes to apoptosis in mice lacking AIM, a novel murine macrophage-derived soluble factor belonging to the scavenger receptor cysteine-rich domain superfamily. J. Exp. Med. 1999; 189:413-22._x000B_2) Haruta I, Kato Y, Hashimoto E, et al. Association of AIM, a novel apoptosis inhibitory factor, with hepatitis via supporting macrophage survival and enhancing phagocytic function of macrophages. J. Biol. Chem. 2001; 276:22910_x000B_3) Kuwata K, Watanabe H, Jiang S-Y, et al. AIM inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice. Am. J. Path. 2003; 162:837-47.
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.