Information

Catalog number

STA-321

Full name

OxiSelect DNA Double-Strand Break (DSB) Staining Kit

Size

100 assays

Price

675.00 €

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Details

Shipping Temp

Blue Ice

Storage Temp

-20ºC

Category (Product Type)

Kit

URL link to SDS

(STA-321) GHS.pdf

UNSPSC

41116100

Product Line

Oxidative Stress/Damage

Short Description

Double-strand breaks (DSB) in DNA are among the most dangerous types of DNA damage occuring within cells. One of the earliest cellular responses to double-strand breaks is the phosphorylation of a histone variant, H2AX, at the sites of DNA damage. Within seconds Ser139 is phosphorylated when DSBs are induced in mammalian cells. Phosphorylation of this serine residue causes chromatin condensation and appears to play a critical role in the recruitment of repair or damage-signaling factors to the DNA damage sites. The OxiSelect™ DNA Double-Strand Break Staining Kit provides an easy-to-use method for detecting the presence of DSBs in cells cultured in microtiter plates. Double strand breaks can be detected in just a few hours by immunofluorescence staining of the phosphorylated histone H2AX.

Product feature 1

Detects phosphorylation of histone H2A.X

Product feature 2

See immunofluorescence in about 3 hours

Product feature 3

DNA double-strand break inducer included