Information
Catalog number
SIH-331-1MG
Full name
mlN4924, NEDD8 activating enzyme inhibitor
Size
1 mg
Price
1023.00 €
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Stock availabilitIn Stock
In Stock
CAS number
905579-51-3
Description
NEDD8 activating enzyme inhibitor
Molecular weight
443,2 g/mol
Primary research fields
Cancer, Apoptosis
Other name
[(1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, Sulfamic acid
Product category
Small Molecules
Product type
Inhibitor
Chemical formula
C21H25N5O4S
Origin
Synthetic
Purity pourcentage
>98%
Soluble in
Soluble in 10 mg/ml DMSO
Physical appearance
White Powder
Storage recommendations
-20ºC
Shipping recommendations
Shipped Ambient
Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
PubChem number
16720766
Scientific context
Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.
Bibliography
1. Soucy T.A., et al. (2009) Nature. 458:732. 2. Milhollen M.A., et al. (2010) Blood. 116:1515.
Release date
6-Jun-2012
PubMed number
Refer to PubMed
Tested applications
To be tested
Tested reactivity
To be tested
Representative figure legend
Chemical structure of MLN4924 (SIH-331), a Nedd8 activating enzyme inhibitor. CAS #: 905579-51-3. Molecular Formula: C21H25N5O4S. Molecular Weight: 443.2 g/mol. Chemical structure of MLN4924, a Nedd8 activating enzyme inhibitor (SIH-331). CAS # 905579-51-3. Molecular Formula: C21H25N5O4S.
Warning information
Non-hazardous
Country of production
Canada
Total weight (kg)
0.25
Net weight (g)
0.001
Additional description
Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.