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mlN4924, NEDD8 activating enzyme inhibitor

Information

Catalog number

SIH-331-200UG

Full name

mlN4924, NEDD8 activating enzyme inhibitor

Size

200 µg

Price

306.00 €

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Details

Stock availabilitIn Stock

In Stock

CAS number

905579-51-3

Description

NEDD8 activating enzyme inhibitor

Molecular weight

443,2 g/mol

Primary research fields

Cancer, Apoptosis

Other name

[(1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, Sulfamic acid

Product category

Small Molecules

Product type

Inhibitor

Chemical formula

C21H25N5O4S

Origin

Synthetic

Purity pourcentage

>98%

Soluble in

Soluble in 10 mg/ml DMSO

Physical appearance

White Powder

Storage recommendations

-20ºC

Shipping recommendations

Shipped Ambient

Safety information

Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes

PubChem number

16720766

Scientific context

Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable.

Bibliography

1. Soucy T.A., et al. (2009) Nature. 458:732. 2. Milhollen M.A., et al. (2010) Blood. 116:1515.

Release date

6-Jun-2012

PubMed number

Refer to PubMed

Tested applications

To be tested

Tested reactivity

To be tested

Representative figure legend

Chemical structure of MLN4924 (SIH-331), a Nedd8 activating enzyme inhibitor. CAS #: 905579-51-3. Molecular Formula: C21H25N5O4S. Molecular Weight: 443.2 g/mol. Chemical structure of MLN4924, a Nedd8 activating enzyme inhibitor (SIH-331). CAS # 905579-51-3. Molecular Formula: C21H25N5O4S.

Warning information

Non-hazardous

Country of production

Canada

Total weight (kg)

0.25

Net weight (g)

0.0002

Additional description

Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.